Calcium control of transmitter release at a cerebellar synapse
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چکیده
منابع مشابه
Calcium control of transmitter release at a cerebellar synapse
The manner in which presynaptic Ca2+ influx controls the release of neurotransmitter was investigated at the granule cell to Purkinje cell synapse in rat cerebellar slices. Excitatory postsynaptic currents were measured using whole-cell voltage clamp, and changes in presynaptic Ca2+ influx were determined with the Ca(2+)-sensitive dye furaptra. We manipulated presynaptic Ca2+ entry by altering ...
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After the arrival of a presynaptic nerve impulse at an excitatory synapse in hippocampal neurons, the rate of neurotransmitter release increases rapidly and then returns to low levels with a biphasic decay. The two kinetically distinct components are differentially affected when Sr2+ is substituted for Ca2+ ions. Our findings are comparable to those of the classical studies for the frog neuromu...
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Dolphin, A. C. and Scott, R. H. (1987) J. Physiol. (London) 386, 1-17 Holz, G. G., Rane, S. G. and Dunlap, K. (1986) Nature (London) 319,670-672 Scott, R. H. and Dolphin, A. C. (1986) Neurosci. Lett. 69,59-64 Lewis, D. L., Weight, F. F. and Luini, A. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 9035-9039 Grassi, F. and Lux, H. D. (1989) Neurosci. Lett. 105, 113-1 19 Dolphin, A. C., Huston, E. and S...
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A newly developed deconvolution method (Neher and Sakaba, 2001) allowed us to resolve the time course of neurotransmitter release at the calyx of Held synapse and to quantify some basic aspects of transmitter release. First, we identified a readily releasable pool (RRP) of synaptic vesicles. We found that the size of the RRP, when tested with trains of strong stimuli, was constant regardless of...
متن کاملCalcium and transmitter release.
The mechanism of transmitter release by intracellular Ca has been explored by recording presynaptic Ca concentration ([Ca2+]i) with Ca-sensitive fluorescent dyes and by controlling [Ca2+]i with photosensitive Ca chelators. [Ca2+]i decays slowly (in seconds) after presynaptic action potentials, while transmitter release lasts only a few ms after each spike at fast synapses. Simulations of Ca dif...
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ژورنال
عنوان ژورنال: Neuron
سال: 1995
ISSN: 0896-6273
DOI: 10.1016/0896-6273(95)90155-8